Yu Zhang

###Education
M.D., 2008, Capital Medical University, China
Ph.D., 2013, Georgia Institute of Technology
Postdoctoral fellow, 2013-2018, Boston Children's Hospital, Harvard Medical School

###Research
Antibody diversification generates the numerous antibodies in human body and plays a pivotal role in protecting us from infectious diseases and cancer. Abnormal antibody diversification underlies diseases ranging from immunodeficiency to autoimmunity and contributes to oncogenic translocations in various leukemias and lymphomas. The focus of Zhang lab is to identify mechanisms that promote antibody diversification and suppress associated oncogenic lesions in B lymphocytes. We are particularly interested in how 3D genome organization and chromatin status collaboratively contribute to antibody generation, gene regulation and genome integrity. Projects in the lab employ cell line and mouse models with a variety of state-of-the-art approaches, including CRIPSR/Cas9 mediated genome manipulation and various next generation sequencing techniques. 

Multiple positions are available in the Zhang Lab:

We are seeking highly-motivated postdoctoral researchers, graduate students and research assistants to join our lab. Trainees will have the opportunity to closely collaborate with experts in molecular biology, immunology, and bioinformatics. If you are interested, please do not hesitate to contact us at yzhang22@msu.edu.