Hua Xiao

Professor, Department of Physiology

Faculty, Genetics & Genome Sciences Program

Faculty, Cell & Molecular Biology Program

Professor, BioMolecular Science Gateway

Location: Biomedical Physical Sciences Building

Address: 567 Wilson Rd Rm 3193

Phone: 517-884-5127

Email: xiaoh@msu.edu

Photo of: Hua Xiao

Bio

###Education
1995-2000, Postdoctoral fellow, The Rockefeller University
1990-1995, Ph.D. in Molecular and Medical Genetics, University of Toronto
1978-1983, M.D. The Second Military Medical University, Shanghai, China
###Research Interests
Normal cell differentiation, morphological development, and immune responses to pathogens in multicellular animals require precisely orchestrated gene expression. Nearly all genes are regulated at the level of transcription in cells. This process is controlled by an array of transcription factors at the end of signal transduction pathways. The fact that many oncogenes, tumor suppressors, and viral regulatory genes encode RNA polymerase II transcription factors highlights that perturbation of their normal regulation can have a devastating impact on gene expression, leading to the development of human diseases, such as cancer. The overall objective of Xiao’s laboratory is to study the molecular mechanisms by which two transcription cofactors, Tat-interacting protein 30 kDa (TIP30) and nuclear receptor coactivator 5 (NCOA5), suppress oncogenesis in the breast and liver. We have done pioneer work demonstrating that TIP30 and NCOA5 are tumor suppressors in mice and humans and reported first that NCOA5 is a genetic link between type 2 diabetes and hepatocellular carcinoma (HCC) (Ito M… Xiao H. (2003). Cancer Research, 63: 8763-7, and Gao S…Xiao H. (2013), Cancer Cell, Volume 24, Issue 6, Pages 725–737). Ultimately, we aim to understand the mechanisms maintaining normal development and underlying tumorigenesis.
Our ongoing studies in the laboratory investigate the molecular and cellular mechanisms by which NCOA5 and TIP30 regulate sex disparities and immunosuppressive responses in the initiation and progression of HCC (Zhang Y...Xiao H (2023). Cell Reports, 31;42(10):113-157; Zhang Y...Xiao H (2024).Cell Mol Gastroenterol Hepatol. 17(1):1-27).

Selected Publications

Gao S, Li A, Liu F, Chen F, Williams M, Zhang C, Kelley Z, Wu CL, Luo R, Xiao H. NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell. 2013 Dec 9;24(6):725-37. PubMed PMID: 24332041; PubMed Central PMCID: PMC3891053.
Gao S, Zhang Y, Yang C, Perez GI, Xiao H. NCOA5 Haplo-insufficiency Results in Male Mouse Infertility through Increased IL-6 Expression in the Epididymis. Sci Rep. 2019 Oct 29;9(1):15525. PubMed PMID: 31664153; PubMed Central PMCID: PMC6820533
Liu X, Liu F, Gao S, Reske J, Li A, Wu CL, Yang C, Chen F, Luo R, Xiao H. A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation. Cancer Lett. 2017 Apr 10;391:152-161.. PubMed PMID: 28137631; PubMed Central PMCID: PMC5391530.
Williams M, Liu X, Zhang Y, Reske J, Bahal D, Gohl TG, Hollern D, Ensink E, Kiupel M, Luo R, Das R, Xiao H. NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin. Oncogene. 2020 May;39(19):3821-3836. PubMed PMID: 32203160; PubMed Central PMCID: PMC7210077.
Yi Q, Wang J, Liu T, Yao Y, Loveless I, Subedi K, Toor J, Adrianto I, Xiao H, Chen B, Crawford HC, Fang D, Zhou L, Mi QS. scRNA-Seq and imaging mass cytometry analyses unveil iNKT cells-mediated anti-tumor immunity in pancreatic cancer liver metastasis. Cancer Lett. 2023 May 1;561:216149. PubMed PMID: 36990268.
Zhang Y, Liu X, Sun K, Luo Y, Yang J, Li A, Kiupel M, Fenske S, Biel M, Mi QS, Wang H, Xiao H. Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner. Cell Rep. 2023 Oct 31;42(10):113157. PubMed PMID: 37733590; NIHMSID: NIHMS1941863.
Zhang Y, Luo Y, Liu X, Kiupel M, Li A, Wang H, Mi QS, Xiao H. NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma. Cell Mol Gastroenterol Hepatol. 2024;17(1):1-27. PubMed PMID: 37734594; PubMed Central PMCID: PMC10665956.