Yun Liang
Assistant Professor, Department of Physiology
Assistant Professor, BioMolecular Science Gateway
Location: Interdisciplinary Science and Technology Building
Address: 766 Service Drive, Room 5010
Phone: 517-353-4945
Email: liangy40@msu.edu
Bio
[Liang Lab Website] (https://sites.google.com/msu.edu/lianglab/home) ###Education 2007, B.S. in Biological Sciences, Tsinghua University 2013, Ph.D. in Biomedical Sciences, University of California San Diego and the Salk Institute for Biological Studies 2015-2018, Postdoctoral training, University of Michigan ###Research Overview Our lab studies sex differences in biology and diseases. We ask why these sex differences exist. We hypothesize that sex differences are important to the biology of the species such that they are selected during evolution. In humans, one of the most remarkable differences between men and women is represented in the manifestation of immune-associated diseases. Many autoimmune diseases feature increased prevalence in females (~78% female overall and up to ~ 95% female for specific diseases). In contrast, infectious diseases affect more men than women. These phenotypic variations are determined by molecular differences between the two sexes as well as their interactions with the environment. One way by which we test our hypothesis is to study the function of these molecular determinants of sex differences, with a focus on immune responses. We use a combination of -omic, molecular, cell-based, and animal-based approaches. We hope our research will eventually lead to novel ways to prevent or treat autoimmune and infectious diseases, which remain major public health issues. Meanwhile, we pose this hypothetical question – if sex-biased autoimmunity/infection is a direct result of evolution, how will its eradication shape the future of human beings? ###Opportunities: We are passionate about science and serious about the career development of future scientists and professionals. To join us, please contact Dr. Yun Liang via email: liangy40@msu.edu To learn more about Dr. Liang and her research goals, go to the following link: https://physiology.natsci.msu.edu/physiology-news/department-of-physiology-welcomes-newest-faculty-member.aspx
Selected Publications
- Carp DM, Liang Y. (2022) Universal or personalized mesenchymal stem cell therapies: impact of age, sex, and biological sources. Cells, 11(13). doi 10.3390/cells11132077.
- Liang Y, Tsoi LC, Xing X, Sarkar MK, Berthier CC, Stuart PE, Nair RP, Elder JT, Voorhees JJ, Kahlenberg JM, Gudjonsson JE. (2017) A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases. Nat Immunol,18(2):152-160.
- Pagenkopf A, Liang Y. (2020) Immunometabolic function of the transcription cofactor VGLL3 provides an evolutionary rationale for sexual dimorphism in autoimmunity. FEBS Lett, 594(20): 3371-3383.
- Shaw TM, Zhang W, McCoy SS, Pagenkopf A, Carp DM, Garg S, Parker MH, Qiu X, Scofield RH, Galipeau J, Liang Y. (2022) X-linked genes exhibit miR6891-5p-regulated skewing in Sjögren’s syndrome. J Mol Med, 100(9):1253-1265.
- Wijdeven RH, Cabukusta B, Behr FM, Qiu X, Amiri D, Borras DM, Arens R, Liang Y, Neefjes J. (2022) CRISPR Activation Screening Identifies VGLL3-TEAD1-RUNX1/3 as a Transcriptional Complex for PD-L1 Expression. J Immunol, 209(5):907-915.