Kin Sing Stephen Lee

My research program _develops chemical biology methods to study lipid pharmacology and designs and synthesizes inhibitors of lipid metabolism to treat neurodegenerative diseases_. During my postdoctoral training at the University of California Davis with National Academy Science Fellow and University Distinguish Professor, Dr. Bruce Hammock, we developed a drug candidate to treat diabetic neuropathy and is currently in Phase I clinical trial. Since I started my independent career at Michigan State University, I have been funded by NIH, NSF, USDA, Michigan Economic Development Corporation, and Pearl Aldrich Endowment fund to conduct areas of research that have both basic and translational aspects: 
**Project 1**: Investigate the molecular crosstalk between polyunsaturated fatty acid metabolism, ferroptosis, and neurodegeneration using a combination of organic synthesis, state-of-the-art metabolomics, and a novel biological model organism 
**Project 2**: Design and synthesize novel metabolic enzyme inhibitors to treat neurodegenerative diseases by applying a multiparameter optimization approach and a novel computational model. 
**Project 3**: Identify biomarkers for aging and neurodegeneration using state-of-the-art analytical instrumentations.