Eran Andrechek
Professor, Department of Physiology
Faculty, Cell & Molecular Biology Program
Faculty, Genetics & Genome Sciences Program
Professor, BioMolecular Science Gateway
Location: Biomedical Physical Sciences Building
Address: 567 Wilson Rd Rm 2194
Phone: 517-884-5042
Email: andrech1@msu.edu
Website: http://lab.andrechek.com/
Bio
###Research Interests The progression of human breast cancer and cancer in general, is a process that is unique among each individual. The mutations that occur in each individual tumor give rise to tumors that are largely heterogeneous when compared to each other. The heterogeneity present within cancer presents a significant obstacle in both elucidating the various mechanisms of transformation and in the development of therapies. When recent work that elucidated the mutational spectrum and pathway activation is considered with the mindset of progression towards therapy, the importance of recognizing the particular genomic signature of an individual tumor becomes quite apparent. Work in my laboratory is focused on understanding mammary tumor development and employs a number of methods to do so, ranging from animal models to computational analysis of gene expression data. We use an integrative method whereby we use bioinformatic methods to make predictions for the role of specific signaling pathways in tumor biology that are then tested using model systems. Current research projects in the laboratory include an analysis of heterogeneity in mouse models of breast cancer through signaling pathway signatures, a determination of the role of the E2F transcription factors in several models of breast cancer, characterization of the development of the mammary gland in the absence of the E2Fs and modeling individualized therapy in a transgenic system.
Selected Publications
- Deanna Acosta, Pilib O’Broin, Daniel Hollern, John M Greally, Aaron Golden, Eran Andrechek, Teresa Wood, Cristina Montagna (2016) Transcriptome Profiling Supports LPA Receptor Activity in Enriched Mammary Epithelial Cell Populations During Postnatal Development, Sci Rep. Nov 3;6:35810. doi: 10.1038/srep35810.
- Jing-Ru Jhan and Eran R. Andrechek (2016) Stat3 regulates tumor latency and growth rate but not metastasis in Myc induced breast cancer, Oncotarget, Aug 29. doi: 10.18632/oncotarget.11667.
- Jing-Ru Jhan and Eran R. Andrechek (2017) Effective personalized therapy for breast cancer based on predictions of cell signaling pathway activation from gene expression analysis, Oncogene, In Press. doi: 10.1038/onc.2016.503.
- Jonathan Rennhack and Eran R. Andrechek (2016) Conserved E2F mediated metastasis in mouse models of breast cancer and HER2 positive patients, Oncoscience, DOI: 10.18632/oncoscience.259
- Jonathan Rennhack, Briana To, Harrison Wermuth and Eran R. Andrechek, (2017) Mouse models of breast cancer share amplification and deletion events with human breast cancer, Journal of Mammary Gland Biology and Neoplasia, In Press. doi: 10.1007/s10911-017-9374-y.
- Lance D. Miller, Eric Jimenez, Jeff A. Chou, Michael A. Black, Cristin Print, Julia Chifman, Angela Alistar, Thomas Putti, Xiaobo Zhou, Davide Bedognetti, Ashok Pullikuth, Jonathan Rennhack, Eran R. Andrechek, Sandra Demaria, Ena Wang, Francesco M. Marincola (2016) Gene Classifiers of Immune Responsiveness Suggest Immunogenic Subtypes of Breast Cancer. Cancer Immunology Research, 4(7):600-10. doi: 10.1158/2326-6066.CIR-15-0149.
- Rennhack J, Swiatnicki M, Zhang Y, Li C, Bylett E, Ross C, Szczepanek K, Hanrahan W, Jayatissa M, Hunter K and Andrechek E, (2019) Integrated sequence and gene expression analysis of mouse models of breast cancer reveals critical events with human parallels Nature Communications, 10(1):3261. doi: 10.1038/s41467-019-11236-3.