Sarah E Elzinga

Assistant Professor, Department of Physiology
Assistant Professor, Neuroscience Program
Assistant Professor, BioMolecular Science Gateway
Location: 5012 766 Service Rd Room 5012
Profile photo of  Sarah E Elzinga
Photo of: Sarah E Elzinga

Bio

Dr. Sarah Elzinga was first introduced to research at Michigan State University where she completed her Master's degree with Dr. Brian Nielsen in the Department of Animal Science and Dr. Ray Geor in the Department of Large animal Clinical Sciences. For her Masters, she investigated the impact of age on nutrient digestibility in horses, which led her to pursue her Ph.D. at the University of Kentucky. Under the guidance of Dr. Amanda Adams, Dr. Elzinga received her Ph.D. in Veterinary science with an emphasis on how the immune system is dysregulated in horses with metabolic syndrome, including how nutrition might be used to modulate that dysregulation. Following her time in Kentucky, Dr. Elzinga transitioned to working in preclinical and translational research at the University of Michigan as a postdoctoral fellow with Dr. Eva Feldman. There, her work expanded to include the effects of metabolic dysregulation (obesity, prediabetes, and diabetes) and their resulting inflammation and immune system dysregulation on the nervous system. Specifically, her research program, which she is now growing now at Michigan State University, is focused on understanding how inflammation and immune system mechanisms promote cognitive impairment and dementias in people with obesity, prediabetes, and diabetes, particularly as they age.

Selected Publications

  • cGAS/STING and innate brain inflammation following acute high-fat feeding View Publication
  • Glial-neuron crosstalk in health and disease: A focus on metabolism, obesity, and cognitive impairment View Publication
  • Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice View Publication
  • Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity View Publication
  • The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease View Publication