Shailendra Giri

The major goal of Giri’s research program is to understand the role of metabolic derangement in multiple sclerosis (MS) and other neurological diseases. The Giri lab focuses on research in areas of metabolism, resolution of disease and immune response, and neuroinflammation & Blood-based Biomarker. Specific projects include:

- Understanding the factors responsible for pathogenesis of MS using preclinical mouse models and various genes/ cell specific knockout mice. 
- Identify blood-based metabolites and altered metabolic pathways in MS patients using cutting edge technologies in the field of metabolism, that can be used to monitor MS progression and response to therapy. 
- Elucidate the relationship between metabolic alteration and functional outcome including immune response and myelination/remyelination.
- Identify why disease resolving system is broken during chronic inflammation.

Our approach of bed to bench and back to bench for translational purposes, will not only provide a better understanding of the etiopathogenesis of MS but will also allow for development of novel therapeutic modalities to cure this disease.