Hongsheng Gui

My research focuses on identifying genetic biomarkers and gene x environment interactions involved in the development of neuropsychiatric diseases (e.g., schizophrenia, suicidality, and substance use disorders). Leveraging on accessible large-scale biobanking datasets (e.g., UK Biobank project, All of Us research program), my team conducts integrative omics analyses to link electronic health records with genomic data for earlier disease diagnosis and risk prediction with biobehavioral-level mechanistic evidence. I am also interested in reducing health disparities across diverse populations, through cross-ethnic meta-analysis and mega analysis. To speed up precision psychiatry, we are currently working on following projects: 1) estimate disease effect estimates for mental health conditions (schizophrenia and suicidality) in diverse populations and apply an ancestry-tailored risk component to polygenic risk scores; 2) investigate adverse drug reactions (especially for HLA region) and treatment response during medication-assisted treatment for major depressive disorder and opioid use disorder (OUD); 3) reveal correlation and causation relationship between OUD and suicidal attempt using multivariate statistical tools.