Jaspreet Singh

The major focus of Singh lab is to investigate the cellular and molecular mechanisms of neurodegneration, develop biomarkers and test novel therapeutic strategies for a X-linked adrenoleukodystrophy (X-ALD). X-ALD is a severe demyelinating neurodevelopmental disorder caused by mutation or deletion in ABCD1 gene that encodes a peroxisomal integral membrane protein-ALDP.  The disease has two major phenotypes, the mild adrenomyeloneuropathy (AMN) and the severe cerebral adrenoleukodystrophy (cALD). cALD has a poor prognosis; no diagnostic biomarker is available to predict its onset and its mechanism of progression remains poorly understood. We utilize knock-out mouse models, patient iPSC-derived neuronal cell and patient plasma samples in our studies. The specific focus of the lab is on deciphering the integrated role of microRNA and metabolomics in onset and progression of disease. There are opportunities for those interested in hands-on bench experiments (gene editing, microRNA analysis, metabolomic rewiring in disease) as well as candidates interested in highthrouput data analysis (RNAseq, metabolomics, lipidomics, transcriptomics and machine learning).